Ketamine vs Spravato: What's the Difference?
- Pine Ridge Mental Healthcare
- 6 days ago
- 1 min read
Ketamine and Spravato both target glutamate but differ in formulation, FDA approval, and treatment requirements.

Ketamine and Spravato are related treatments but are not the same. Pine Ridge Mental Healthcare offers both options and helps patients determine which is most appropriate based on medical history, age, and insurance coverage.
Ketamine Therapy
Off-label use for mental health
Can be administered in-office or at home
Requires careful monitoring and follow-up
Spravato® (Esketamine)
FDA-approved for treatment-resistant depression
Administered in-office only
Required for patients with Medicaid coverage
Recommended for patients over 65 or with significant medical conditions
Intrested in our other articles on Ketamine and Spravato? Click below!
Treatment For Long-Term Success
At Pine Ridge Mental Healthcare, we’ve found success using a variety of approaches to major depressive disorder. Discussing these approaches with a trusted provider is the first and most important step. Getting your depression under control is a key to improving how you feel.
Our mental health team works to reduce your reliance on medications by educating you about the different tools available and how life situations can affect your mood. In addition, we help keep you on track with regular check-ins to monitor how you are doing.
For help managing your health, schedule an appointment online or over the phone at Pine Ridge Mental Healthcare in Owasso, Oklahoma. If you are interested in other services we provide, check out our services page.
This content was written and reviewed by Pine Ridge Mental Healthcare, an outpatient psychiatry clinic in Oklahoma. Treatment decisions are made by licensed psychiatric providers based on individual evaluation.