Post-Traumatic Stress Disorder (PTSD) can affect every aspect of a person’s life — from sleep and relationships to work, emotional stability, and physical health. Many individuals living with PTSD feel trapped in cycles of anxiety, intrusive memories, and emotional distress.

This guide breaks down the difference between ketamine and esketamine, how each works, and how to determine which option may be right for you.

Ketamine-based treatments, including oral ketamine and Spravato® (esketamine), can be transformative for treatment-resistant depression, PTSD, and severe anxiety. While the medication does powerful neurological work on its own (increasing neuroplasticity and glutamate signaling), your mindset, preparation, and aftercare significantly influence the experience and long-term benefit.