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Oral Ketamine Treatment

Oral Ketamine: An Innovative Approach to Mental Health Management

Oral ketamine is a groundbreaking health care treatment for a variety of mental health problems effecting your daily life. This page provides an overview of how oral ketamine works, its benefits, contraindications, at-home delivery, as well as its potential advantages over Spravato. It is important to note that while oral ketamine is an FDA off-label treatment, it has shown promising results for PTSD, anxiety, depression, chronic pain relief, and OCD.

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What is Ketamine and How Does It Work?

Ketamine was first created as an anesthetic in the 1960s. It works by blocking NMDA receptors in the brain. This causes an increase in a chemical called glutamate, which is found in brain cells. This glutamate is also called a neurotransmitter and is important for brain communication and function. More glutamate activity helps improve mood and brain functions, which can quickly decrease signs and symptoms of mental health issues.

Benefits of Oral Ketamine

Oral ketamine has demonstrated significant benefits in the treatment of various medical conditions. It is particularly helpful for those that are resistant to conventional treatment plans.

Mental Health Benefits

  • Depression: Rapid relief of depressive symptoms, often within hours to days.

  • PTSD: Reduction in symptoms of post-traumatic stress disorder, including flashbacks and anxiety.

  • Anxiety: Improve or eliminate anxiety symptoms, providing a sense of calm and well-being.

  • OCD: Improvement in obsessive-compulsive disorder symptoms by reducing intrusive thoughts and compulsive behaviors.

Reasons Not To Take Oral Ketamine

While oral ketamine is beneficial for many, it is not suitable for everyone. Certain conditions and factors may prohibit its use.

  • Unwanted side effects, such as tiredness or elevated blood pressure.

  • Pregnancy and Breastfeeding: Not recommended because of potential risks to the fetus.

  • Uncontrolled Hypertension: Ketamine can increase blood pressure, posing risks for those with hypertension.

  • History of Substance Abuse: Potential for abuse and dependence necessitates caution in individuals with a history of substance abuse.

  • Severe Heart Disease Conditions: May exacerbate heart conditions due to its cardiovascular blood pressure effects.

  • Psychotic Disorders: Can worsen symptoms in individuals with schizophrenia or other psychotic disorders if not stable.

Oral ketamine represents a promising treatment option for a range of mental health conditions. It is particularly helpful for those who have not responded to traditional therapies. Its unique way of working makes it a great alternative to other treatments. The convenience of online appointments makes getting better even easier.​


How Does At-Home Oral Ketamine Work?

Starter Series

4 Sessions Over 2 Weeks

Continuing Series

8 At-Home Ketamine Sessions 


Currently oral at-home ketamine therapy is NOT a covered benefit by any insurance plan. This is because it is regarded as an “off-label” use for disorders such as anxiety, depression, OCD, and PTSD. As a result, insurances will not reimburse for treatment. as well as other credit cards may be an option for patients who qualify.

Starter Series


Per Session



Continuing Series


Per Session



Spravato and Ketamine Compared

While both oral ketamine and Spravato (esketamine) offer significant benefits, there are several reasons why oral ketamine might be considered over Spravato for some patients.

Advantages of Oral Ketamine

  • Medicine Delivery: Oral ketamine can be prescribed by a mental health professional and taken at home. This provides greater convenience compared to Spravato, which requires administration in a clinical office setting.

  • Cost-Effectiveness: Generally, oral ketamine can be more affordable than Spravato, depending on insurance reimbursement and transportation issues. 

  • Dosing Flexibility: Oral ketamine allows for more precise dosing adjustments tailored to individual patient needs.

  • Ease of Access: Virtual visit options make oral ketamine accessible to more people. It is especially helpful for those in remote areas.

  • More Coverage Options: Oral Ketamine can be used to treat depression, anxiety, PTSD, OCD, and chronic pain. In contrast, Spravato can only be currently used to treat symptoms of depression.

FDA Off-Label Treatment

Oral ketamine is used off-label for several mental health conditions. Off-label use means that while it is not specifically approved by the FDA to treat a problem, substantial evidence supports its efficacy and safety (see further resources below).

Conditions Treated Off-Label with oral Ketamine

  • PTSD: Effective in reducing symptoms and improving overall functioning.

  • Anxiety: Provides rapid relief from generalized anxiety and panic disorders.

  • Depression: Particularly beneficial for treatment-resistant depression.

  • Chronic Pain: Alleviates various forms of chronic pain, improving quality of life.

  • OCD: Reduces the severity of obsessive-compulsive symptoms.

happy, laughing women

Mental Health Treatment For long-term Success


At Pine Ridge Mental Healthcare, we’ve found success using a variety of approaches to mental health disorders. Getting your mental health under control is a key step in managing your life. This section discusses oral ketamine in detail. If you are interested in finding out more about Spravato, then simply click below.


Our team works to reduce reliance on medications by educating about the different tools available and how life situations can affect mood. And we help keep you on track with regular check-ins to monitor your health.


For more information about mental health disorders or for help managing another health goal, schedule an appointment online or over the phone at Pine Ridge Mental Healthcare. If you are interested in other services we provide, check out our services page. 

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Get in touch so we can start working together.

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