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Exploring the Uses of Ketamine in Treatment

  • Writer: Pine Ridge Mental Healthcare
    Pine Ridge Mental Healthcare
  • 1 day ago
  • 5 min read

Ketamine has a long history as an anesthetic, but its role in treating mental health conditions is something many people are just beginning to understand. Over the years, research and clinical practice have shown that ketamine can be a powerful tool for helping people who struggle with depression, anxiety, and other psychiatric conditions. Today, I want to share what the uses of ketamine in treatment are, how it works, and what it might mean for those seeking new paths to wellness.


Understanding the Uses of Ketamine in Mental Health


Ketamine is a medication that was originally developed for anesthesia. However, in recent years, it has gained attention for its rapid effects on mood and mental health symptoms. Unlike traditional antidepressants, which can take weeks to work, ketamine often provides relief within hours or days. This makes it especially valuable for people who have not responded well to other treatments.


Ketamine is used in various ways in mental health care:


  • Treatment-resistant depression: Many people with depression do not find relief from standard medications. Ketamine can offer a new option for these individuals.

  • Post-traumatic stress disorder (PTSD): Some studies suggest ketamine helps reduce symptoms of PTSD by altering how the brain processes traumatic memories.

  • Anxiety disorders: Ketamine may ease severe anxiety, especially when other treatments have failed.

  • Suicidal ideation: Because of its fast-acting nature, ketamine can be life-saving for people experiencing suicidal thoughts.


If you’re wondering what is ketamine used for, these are some of the key areas where it has shown promise.


Eye-level view of a medical clinic room prepared for ketamine treatment

How Ketamine Works in the Brain


One of the reasons ketamine is so interesting is because it works differently from most psychiatric medications. Traditional antidepressants often target serotonin or norepinephrine, chemicals involved in mood regulation. Ketamine, on the other hand, affects a brain receptor called NMDA (N-methyl-D-aspartate).


By blocking NMDA receptors, ketamine helps increase the activity of another receptor called AMPA. This leads to a boost in brain connections and the release of growth factors that support brain health. In simple terms, ketamine helps the brain “rewire” itself in a way that can improve mood and reduce symptoms of depression and anxiety.


This process can happen quickly, which explains why many people feel better soon after treatment. However, the effects may not last forever, so ketamine is often part of a broader treatment plan that includes therapy and lifestyle changes.


Different Ways Ketamine is Administered


Ketamine can be given in several forms, depending on the treatment setting and individual needs. Here are the most common methods:


  1. Intravenous (IV) infusion: This is the most studied and widely used method. Ketamine is slowly infused into the bloodstream over about 40 minutes. This allows for precise control of dosage and quick effects.

  2. Intramuscular injection: Ketamine can be injected into a muscle, which is sometimes used in clinical settings.

  3. Nasal spray: A form of ketamine called esketamine is FDA-approved for depression and is administered as a nasal spray under medical supervision.

  4. Oral or sublingual tablets: These are less common and generally less effective but may be used in some cases.


Each method has its pros and cons, and a healthcare provider can help decide which is best based on the individual’s condition and preferences.


Close-up view of a nasal spray bottle used for ketamine treatment

What to Expect During Ketamine Treatment


If you or someone you know is considering ketamine treatment, it’s helpful to know what the experience might be like. Here’s a general overview:


  • Preparation: Before treatment, a thorough evaluation is done to ensure ketamine is safe and appropriate. This includes discussing medical history and current medications.

  • During treatment: For IV infusions, you’ll be seated comfortably while the medication is administered. You might feel lightheaded, relaxed, or experience mild dissociation (a sense of detachment from your body or surroundings). These effects usually pass quickly.

  • After treatment: Many people notice mood improvements within hours. Some may need multiple sessions over several weeks to maintain benefits.

  • Follow-up care: Ketamine is often combined with therapy and other supports to help sustain progress.


It’s important to have treatment in a safe, supervised environment with trained professionals. This ensures the best outcomes and minimizes risks.


Who Can Benefit from Ketamine Treatment?


Ketamine is not a one-size-fits-all solution, but it can be a game-changer for many people. Those who might benefit include:


  • Individuals with severe depression that hasn’t improved with other treatments.

  • People experiencing suicidal thoughts who need rapid relief.

  • Those with PTSD or anxiety disorders who have not found success with traditional therapies.

  • Patients looking for alternative options when medications cause unwanted side effects.


It’s also important to note that ketamine treatment is not suitable for everyone. People with certain medical conditions, such as uncontrolled high blood pressure or a history of psychosis, may not be good candidates. A thorough medical and psychiatric evaluation is essential.


Supporting Long-Term Mental Health with Ketamine


While ketamine can provide quick relief, lasting mental health requires ongoing care. Here are some ways to support long-term wellness alongside ketamine treatment:


  • Therapy: Combining ketamine with talk therapy can help process emotions and develop coping skills.

  • Healthy lifestyle: Regular exercise, balanced nutrition, and good sleep habits support brain health.

  • Mindfulness and relaxation: Practices like meditation or yoga can reduce stress and improve mood.

  • Social support: Staying connected with friends, family, or support groups is vital.


At Pine Ridge Mental Healthcare, we focus on personalized care that addresses all aspects of mental health. Ketamine is one tool among many that can help people find hope and healing.


Looking Ahead: The Future of Ketamine in Mental Health Care


The use of ketamine in treatment is still evolving. Researchers continue to study how it works, who benefits most, and how to make it safer and more accessible. New forms of ketamine and related medications are being developed to improve effectiveness and reduce side effects.


As awareness grows, more people will have access to this innovative treatment. It’s exciting to think about the possibilities for those who have struggled for years without relief.


If you or someone you care about is exploring options, remember that help is available. Ketamine treatment, combined with compassionate care, can open doors to a brighter future.


Intrested in our articles on depression? Click below:


Treatment For Long-Term Success


At Pine Ridge Mental Healthcare, we’ve found success using a variety of approaches to major depressive disorder. Discussing these approaches with a trusted provider is the first and most important step. Getting your depression under control is a key to improving how you feel.


Our mental health team works to reduce your reliance on medications by educating you about the different tools available and how life situations can affect your mood. In addition, we help keep you on track with regular check-ins to monitor how you are doing.


For help managing your health, schedule an appointment online or over the phone at Pine Ridge Mental Healthcare in Owasso, Oklahoma. If you are interested in other services we provide, check out our services page.

This content was written and reviewed by Pine Ridge Mental Healthcare, an outpatient psychiatry clinic in Oklahoma. Treatment decisions are made by licensed psychiatric providers based on individual evaluation.

At Pine Ridge Mental Healthcare, we believe everyone deserves compassionate, personalized care. If you or someone you love is struggling, reaching out for help is a brave and important step.



If you want to explore more about how depression impacts your relationships and find resources to support you, visit Pine Ridge Mental Healthcare.


Remember, you are not alone on this journey. Together, we can find ways to heal and connect.

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